Your choice of airline really matters and because you are going to marry one be sure to do your homework to prevent a bitter divorce. The most important decision when choosing an airline is to try and find one with non-stop service to your most common destinations. While you may not mind lay-overs and can benefit from the rewards of multiple segments especially for travel of short distances, they significantly increase the time of trips and increase the chances of being delayed.
Once you have narrowed down the choices, you should look to see what the remaining airlines offer in terms of amenities and incentives. You can search online for individual airlines, but I have included my thoughts on some of the airlines I have traveled. You will notice a lot of airlines are not listed as I do not have enough experiences with them to comment. From what I have heard from others, JetBlue is one of the best airlines. I plan to travel with them soon and will comment when I do.